diff --git a/quic/core/quic_connection.cc b/quic/core/quic_connection.cc
index bb0db5c..b7c9bb4 100644
--- a/quic/core/quic_connection.cc
+++ b/quic/core/quic_connection.cc
@@ -4206,6 +4206,13 @@
   SetRetransmissionAlarm();
   if (acked_new_packet) {
     OnForwardProgressMade();
+  } else if (default_enable_5rto_blackhole_detection_ &&
+             !sent_packet_manager_.HasInFlightPackets() &&
+             blackhole_detector_.IsDetectionInProgress()) {
+    // In case no new packets get acknowledged, it is possible packets are
+    // detected lost because of time based loss detection. Cancel blackhole
+    // detection if there is no packets in flight.
+    blackhole_detector_.StopDetection();
   }
 
   if (send_stop_waiting) {
@@ -4707,16 +4714,15 @@
 }
 
 void QuicConnection::OnBlackholeDetected() {
-  QUIC_BUG_IF(default_enable_5rto_blackhole_detection_ &&
-              !sent_packet_manager_.HasInFlightPackets())
-      << ENDPOINT
-      << "Closing connection because of blackhole, but there is no bytes in "
-         "flight";
-  const std::string error_detail = quiche::QuicheStrCat(
-      "Network blackhole detected", sent_packet_manager_.HasInFlightPackets()
-                                        ? "."
-                                        : " with no packets in flight.");
-  CloseConnection(QUIC_TOO_MANY_RTOS, error_detail,
+  if (default_enable_5rto_blackhole_detection_ &&
+      !sent_packet_manager_.HasInFlightPackets()) {
+    QUIC_BUG << ENDPOINT
+             << "Blackhole detected, but there is no bytes in flight, version: "
+             << version();
+    // Do not close connection if there is no bytes in flight.
+    return;
+  }
+  CloseConnection(QUIC_TOO_MANY_RTOS, "Network blackhole detected",
                   ConnectionCloseBehavior::SEND_CONNECTION_CLOSE_PACKET);
 }
 
diff --git a/quic/core/quic_connection_test.cc b/quic/core/quic_connection_test.cc
index 5340233..d80ca65 100644
--- a/quic/core/quic_connection_test.cc
+++ b/quic/core/quic_connection_test.cc
@@ -11698,6 +11698,70 @@
   connection_.GetPingAlarm()->Fire();
 }
 
+// Regression test for b/159698337
+TEST_P(QuicConnectionTest, DuplicateAckCausesLostPackets) {
+  if (!GetQuicReloadableFlag(quic_default_enable_5rto_blackhole_detection2)) {
+    return;
+  }
+  // Finish handshake.
+  connection_.SetDefaultEncryptionLevel(ENCRYPTION_FORWARD_SECURE);
+  peer_creator_.set_encryption_level(ENCRYPTION_FORWARD_SECURE);
+  notifier_.NeuterUnencryptedData();
+  connection_.NeuterUnencryptedPackets();
+  connection_.OnHandshakeComplete();
+  EXPECT_CALL(visitor_, GetHandshakeState())
+      .WillRepeatedly(Return(HANDSHAKE_COMPLETE));
+
+  std::string data(1200, 'a');
+  // Send data packets 1 - 5.
+  for (size_t i = 0; i < 5; ++i) {
+    SendStreamDataToPeer(
+        GetNthClientInitiatedStreamId(1, connection_.transport_version()), data,
+        i * 1200, i == 4 ? FIN : NO_FIN, nullptr);
+  }
+  ASSERT_TRUE(connection_.BlackholeDetectionInProgress());
+
+  EXPECT_CALL(*send_algorithm_, OnCongestionEvent(_, _, _, _, _)).Times(3);
+
+  // ACK packet 5 and 1 and 2 are detected lost.
+  QuicAckFrame frame =
+      InitAckFrame({{QuicPacketNumber(5), QuicPacketNumber(6)}});
+  LostPacketVector lost_packets;
+  lost_packets.push_back(
+      LostPacket(QuicPacketNumber(1), kMaxOutgoingPacketSize));
+  lost_packets.push_back(
+      LostPacket(QuicPacketNumber(2), kMaxOutgoingPacketSize));
+  EXPECT_CALL(*loss_algorithm_, DetectLosses(_, _, _, _, _, _))
+      .Times(AnyNumber())
+      .WillOnce(DoAll(SetArgPointee<5>(lost_packets),
+                      Return(LossDetectionInterface::DetectionStats())));
+  ProcessAckPacket(1, &frame);
+  EXPECT_TRUE(connection_.BlackholeDetectionInProgress());
+  QuicAlarm* retransmission_alarm = connection_.GetRetransmissionAlarm();
+  EXPECT_TRUE(retransmission_alarm->IsSet());
+
+  // ACK packet 1 - 5 and 7.
+  QuicAckFrame frame2 =
+      InitAckFrame({{QuicPacketNumber(1), QuicPacketNumber(6)},
+                    {QuicPacketNumber(7), QuicPacketNumber(8)}});
+  ProcessAckPacket(2, &frame2);
+  EXPECT_TRUE(connection_.BlackholeDetectionInProgress());
+
+  // ACK packet 7 again and assume packet 6 is detected lost.
+  QuicAckFrame frame3 =
+      InitAckFrame({{QuicPacketNumber(7), QuicPacketNumber(8)}});
+  lost_packets.clear();
+  lost_packets.push_back(
+      LostPacket(QuicPacketNumber(6), kMaxOutgoingPacketSize));
+  EXPECT_CALL(*loss_algorithm_, DetectLosses(_, _, _, _, _, _))
+      .Times(AnyNumber())
+      .WillOnce(DoAll(SetArgPointee<5>(lost_packets),
+                      Return(LossDetectionInterface::DetectionStats())));
+  ProcessAckPacket(3, &frame3);
+  // Make sure loss detection is cancelled even there is no new acked packets.
+  EXPECT_FALSE(connection_.BlackholeDetectionInProgress());
+}
+
 }  // namespace
 }  // namespace test
 }  // namespace quic